In the TV Show Mystery Science Theater 3000, Mike Nelson explains that in his job all he did was play Doom. In a commercial for the episode "The Starfighters", Crow and Mike are playing Doom as Tom Servo introduces the next episode. Moreover, during the episode "Deathstalker and the Warriors from Hell," Mike remarks that a particularly empty gothic-looking scene "is like playing Doom with no monsters or opponents."
Code Monkeys is a show on G4 which takes place in a 1980's game company. In an episode of the show called "Wrassle Mania" John Romero goes on a thirty second pitch meeting with Larrity (the company's boss). As they walk through the hall Romero explains the plot of Doom and Larrity makes fun of it. The hall they walk through is a parody of the actual gameplay of Doom.
Danny Phantom: In episode 12 of season 1, Danny and Tucker play an online FPS/MMORPG called "Doomed", which consists of laser weapons and takes place in destroyed cities on Earth and futuristic buildings. Also in the episode, the villain Nicolai Technus hacks himself into the game and gives himself a mechanical spider-like appearance.
In many movies and television episodes (e.g. Doctor Who, in the episodes The Impossible Planet and The Satan Pit, and the 1994 film The Santa Clause, where the sounds that Santa's reindeer make as Charlie checks them out resemble those of the ones made when Doom's monsters die; specifically, the death sounds of the zombieman/sergeant and the imp), you can hear sound effects which were also used in Doom. This is because many of the effects used in Doom were licensed from the popular Sound Designs library. In some cases, such as The Santa Clause, this may have been done as a deliberate homage to the game.
Doom, as well as "Labyrinth of Death" (Лабиринт Смерти), a fictional virtual reality multiplayer game inspired by Doom ideas and images, is extensively featured in the Labyrinth of Reflections trilogy by Russian author Sergey Lukyanenko.
The film Naqoyqatsi includes a video clip from Doom (at the 1:11:09 mark).
In the film Breakdown, the game Red's son is playing at the house is Doom.
In the film Wild Hogs, a police officer describes how he acquired his badge over the internet, noting that "for firearms training, they just told us to play Doom". After the large fight at the end of the film, he also says "wow, that was like, level twelve of Doom".
In the 12th issue of Concerned, a webcomic made with the Half-Life 2 engine, G-Man briefly mentions the Arch-vile to distract the main character, Gordon Frohman.
The song "My Domain" on the Dark Nebula album Dreamfuel features samples of various speeches from Doom.
Lemon Demon's song "Bad idea" samples death sounds of zombies and demons, teleportation, the rocket launcher, and the super shotgun.
Manny Charlton, the guitarist of Nazareth, sent an untitled song on a cassette tape to id Software in 1995. John Romero would later call the song Blood On the Walls despite Doom being written all over the case. The liner said "For all the guys and gals at I.D. who came up with the coolest game this side of hell, kick some demon butt to this!!" and also said to 'distribute as shareware.'