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When the player meets E. Grafton in Doom 3, he warmly welcomes the player to his job with a slight chuckle, but then tells him he has to do his job.
After the first invasion when the player approaches the console that is requesting an uplink, Grafton can be found on the stairs, dead. A spot of blood on his upper body implies that he met his unfortunate fate from a gunshot. He was either killed by a zombified marine or was turned into a zombie and was shot.